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 产品中心 -- -- Rabbit antibody to c-terminal
产品名称:Rabbit antibody to c-terminal 英文名:
CAS: 参考价格:
规格:100 µl 产地:osenses 货号:OST00053W
产品简介:Rabbit antibody to c-terminal of human Telomerase reverse transcriptase (TERT): whole serum,OST00053W,osenses

Rabbit antibody to c-terminal of human Telomerase reverse transcriptase (TERT): whole serum

Code OST00053W
ID Tag Rb410-200308-WS

Unit size 100 µl
Immunogen A synthetic peptide from c-terminal of human Telomerase reverse transcriptase (HEST2, TP2, TERT, EST2, TCS1, TRT) conjugated to an immunogenic carrier protein was used as the antigen.
Conjugate Unconjugated antibody
Accession
Also known as Telomerase catalytic subunit, HEST2, Telomerase-associated protein 2, HEST2, TP2, TERT, EST2, TCS1, TRT
Background FUNCTION: Telomerase is a ribonucleoprotein enzyme essential for the replication of chromosome termini in most eukaryotes. It elongates telomeres. It is a reverse transcriptase that adds simple sequence repeats to chromosome ends by copying a template sequence within the RNA component of the enzyme.
CATALYTIC ACTIVITY: Deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1).
SUBUNIT: Component of the telomerase ribonucleoprotein complex at least composed of TEP1, EST1A, POT1 and a telomerase RNA template component (TER). Interacts with PINX1 and MCRS1.
SUBCELLULAR LOCATION: Nucleus. Telomere.
DISEASE: Activation of telomerase has been implicated in cell immortalization and cancer cell pathogenesis.
Host NZ white rabbit
Purity Whole serum
Clonality Polyclonal
Isotype Polyclonal, whole serum
Applications IHC, WB. A dilution of 1 : 300 to 1 : 2000 is recommended. The optimal dilution should be determined by the end user.
Specificity Specific for TERT.
Spcs X-react. Human. Other species not yet tested.
Format Lyophilised
Reconstitution Reconstitute in 100 µl of sterile water. Centrifuge to remove any insoluble material.
Storage Maintain the lyophilised/reconstituted antibodies frozen at -20°C for long term storage and refrigerated at 2-8°C for a shorter term. When reconstituting, glycerol (1:1) may be added for an additional stability. Avoid freeze and thaw cycles.
Expiry Date 12 months after reconstitution
Transportation This item will be shipped to you at ambient temperature in a lyophilised form.
References 1. Nakamura T.M, et al. Science 277:955-959(1997).
2. Meyerson M, et al. Cell 90:785-795(1997).
3. Wick M, et al. Gene 232:97-106(1999).
4. Hisatomi H, et al. Neoplasia 5:193-197(2003).
5. Tsakiri K.D, et al. Proc. Natl. Acad. Sci. U.S.A. 104:7552-7557(2007).
6. Nousiainen M, et al. Proc. Natl. Acad. Sci. U.S.A. 103:5391-5396(2006).
Limitation For research use only


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